Very first, we omitted cases clinically determined to have blood pressure level at the standard mainly because users was in fact expected to transform the slimming down habits immediately after seeing risk
Immediately after emptying their bladders, the players seated privately for more than 5 minutes. Their blood circulation pressure are measured using a good calibrated mercury sphygmomanometer because of the an experienced wellness nurse after the a standardized procedure. The participants place its proper arm inside good cuff airbag, counted at least step 1 minute ranging from tracks. We laid out blood circulation pressure people that have a suggest away from SBP ? 140 mmHg, a hateful of DBP ? ninety mmHg, or delivering antihypertensive cures according to advice to possess preventing and you will managing blood pressure level into the China (2010) 23 . Diabetes and you can myocardial infarction was basically defined centered on worry about-statement away from prognosis of the a health care provider in public medical facilities above the condition height. The participants must provide new certificate from diabetic issues or myocardial infarction. Investigators need make certain the brand new person’s prognosis regarding research and you can inquiry all the questions ‘Keeps a health care provider actually provided you the analysis out of diabetes?
Features a doctor actually ever considering you the diagnosis out-of myocardial infarction? Therapy explore is actually laid out in accordance with the participants’ mind-declaration, where detectives must ask the participants the following inquiries: ‘Could you be bringing anti-blood pressure levels pills? Did you make use of the dental drug, shot of insulin, Chinese antique treatments, or home cures to relieve diabetes? According to guidance on cures and you will therapy of bloodstream lipids inside the Chinese adults (2006), players just who satisfied at least one of your own adopting the standards: (1) TC ? six. I along with felt other slimming down covariates, including complete weight reduction times, opportunity, whole grain, meat, good fresh fruit, vegetables, saturated fatty acidic, polyunsaturated fatty acidic, cereal soluble fiber, Na, K, and you will cholesterol intake, since the surrogates to manage prospective weight loss confounding.
The latest collective average consumption out of calcium supplements, magnesium, and you can phosphorus is computed to attenuate inside-person variation which means gain a knowledgeable imagine of the much time-term consumption. Person-numerous years of pursue-right up for every single participant was indeed calculated as interval between your day regarding doing of one’s standard questionnaire in addition to avoid from follow-up (the time of your own past check out and/or visit of stroke diagnosis), almost any showed up basic. This new chance speed try determined of the breaking up exactly how many circumstances from the individual-numerous years of follow-up. New multivariate Cox proportional dangers habits were utilized so you’re able to imagine brand new danger rates (HR) and 95% confidence durations (95% CI) of fabricating coronary attack centered on diet calcium, magnesium, and kod promocyjny seekingarrangement phosphorus intake with the low quartile since the reference class. On Cox proportional danger activities, the newest p for pattern is performed by the acting the latest median out of the kinds discussed from the for each quartile since the a continuous adjustable.
We first performed statistical interaction tests between dietary intakes of calcium, magnesium, phosphorus, and other baseline characteristics (Table 1). We used the Kolmogorov-Sminov test to test the normality of all variables. We outlined the baseline characteristics of the participants. We used the t-test for the continuous variables with normal distribution to test for differences and trends between groups. The non-parametric test is applied to the continuous variables with non-normal distribution, and the chi-square test is used for the classified variables. Then, we categorize the three-day average intakes of calcium, magnesium, phosphorus into four levels. We constructed three sequential models to estimate the effect of calcium, magnesium, phosphorus intakes on stroke. Model 2 further added baseline sociodemographic and lifestyle factors such as urbanization index, education, household income, smoking status, alcohol intake, physical activity, BMI, hypertension, diabetes, myocardial infarction, and medication use into the multivariable analysis. Model 3 additionally adjusted for dietary factors including energy (kcal/d), whole grain (g/d), red meat (g/d), fruits (g/d), vegetables (g/d), saturated fatty acid (g/d), polyunsaturated fatty acid (g/d), cereal fiber (g/d), Na (mg/d), K (mg/d) and cholesterol (g/d) 24,25,26 . To further analyze which factors would affect the relationship between the exposure and outcome, we conducted stratified analyses by age at baseline (< 60 and ? 60 years), sex (man and woman), smoking (never and ever), drinking (never and ever), BMI (< 24, 24–28 and > 28 kg/m 2 ), hypertension, diabetes, and Myocardial infarction. The likelihood ratio test was used to assess the interactions of cross-product terms. The proportional hazards assumption for dietary calcium, magnesium, phosphorus Intakes, and other covariates was checked by Schoenfeld’s residuals, and no violation was found (P > 0.05). Besides, we performed sensitivity analyses to verify the robustness of the primary results. Second, we repeated the analysis using the non-adjusted person-time from the date of the first visit to the time of the most recent visit of stroke diagnosis or to the end of follow-up, whichever came first. Third, we included dyslipidemia as a sensitivity analysis, which confirmed the robustness of our findings to some degree. Tests for trends across dietary intake categories were conducted by modeling the median value in each quartile as a continuous variable in each model. All statistical analyses were performed with STATA version 14.0. All P-values were two-sided, and P < 0.05 was considered to statistical significance.